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Pank1 Deletion in Leptin-deficient Mice Reduces Hyperglycaemia and Hyperinsulinemia and Modifies Global Metabolism without Affecting Insulin Resistance
AIMS/HYPOTHESIS: Pantothenate kinase (PanK) is the first enzyme in coenzyme A (CoA) biosynthesis. Pank1-deficient mice have 40% lower liver CoA and fasting hypoglycaemia that results from reduced gluconeogenesis. Single-nucleotide polymorphisms in the human PANK1 gene are associated with insulin lev...
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| Publicado en: | Diabetologia |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4618598/ https://ncbi.nlm.nih.gov/pubmed/24781151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-014-3245-5 |
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