Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

BACKGROUND: Resistance to chemotherapy is common in gastroesophageal cancer. Mechanisms of resistance are incompletely characterised and there are no predictive biomarkers in clinical practice for cytotoxic drugs. We used new cell line models to characterise novel chemotherapy resistance mechanisms...

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Udgivet i:BMC Cancer
Main Authors: Matula, Kasia, Collie-Duguid, Elaina, Murray, Graeme, Parikh, Khyati, Grabsch, Heike, Tan, Patrick, Lalwani, Salina, Garau, Roberta, Ong, Yuhan, Bain, Gillian, Smith, Asa-Dahle, Urquhart, Gordon, Bielawski, Jacek, Finnegan, Michael, Petty, Russell
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618539/
https://ncbi.nlm.nih.gov/pubmed/26493335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1718-7
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