Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein

Frontotemporal dementia (FTD) is a frequent form of early-onset dementia and can be caused by mutations in MAPT encoding the microtubule-associated protein TAU. Because of limited availability of neural cells from patients’ brains, the underlying mechanisms of neurodegeneration in FTD are poorly und...

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Publicat a:Stem Cell Reports
Autors principals: Ehrlich, Marc, Hallmann, Anna-Lena, Reinhardt, Peter, Araúzo-Bravo, Marcos J., Korr, Sabrina, Röpke, Albrecht, Psathaki, Olympia E., Ehling, Petra, Meuth, Sven G., Oblak, Adrian L., Murrell, Jill R., Ghetti, Bernardino, Zaehres, Holm, Schöler, Hans R., Sterneckert, Jared, Kuhlmann, Tanja, Hargus, Gunnar
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618448/
https://ncbi.nlm.nih.gov/pubmed/26143746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.06.001
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