Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein

Frontotemporal dementia (FTD) is a frequent form of early-onset dementia and can be caused by mutations in MAPT encoding the microtubule-associated protein TAU. Because of limited availability of neural cells from patients’ brains, the underlying mechanisms of neurodegeneration in FTD are poorly und...

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Publicado no:Stem Cell Reports
Main Authors: Ehrlich, Marc, Hallmann, Anna-Lena, Reinhardt, Peter, Araúzo-Bravo, Marcos J., Korr, Sabrina, Röpke, Albrecht, Psathaki, Olympia E., Ehling, Petra, Meuth, Sven G., Oblak, Adrian L., Murrell, Jill R., Ghetti, Bernardino, Zaehres, Holm, Schöler, Hans R., Sterneckert, Jared, Kuhlmann, Tanja, Hargus, Gunnar
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618448/
https://ncbi.nlm.nih.gov/pubmed/26143746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.06.001
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