Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response

The RIG-I-like receptor (RLR) pathway is essential for detecting cytosolic viral RNA to trigger the production of type I interferons (IFNα/β) that initiate an innate antiviral response. Through systematic assessment of a wide variety of genomics data, we discovered 10 molecular signatures of known R...

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Publicado en:PLoS Comput Biol
Autores principales: van der Lee, Robin, Feng, Qian, Langereis, Martijn A., ter Horst, Rob, Szklarczyk, Radek, Netea, Mihai G., Andeweg, Arno C., van Kuppeveld, Frank J. M., Huynen, Martijn A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618338/
https://ncbi.nlm.nih.gov/pubmed/26485378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004553
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