Phosphorylation of the Nuclear Receptor Co-repressor 1 by Protein Kinase B (PKB/Akt) Switches its Co-repressor Targets in the Liver

The nuclear receptor corepressor 1 (NCoR1) is a transcriptional co-regulator that has wide-ranging effects on gene expression patterns. In the liver, NCoR1 represses lipid synthesis in the fasting state, whereas it inhibits the activation of PPARα upon feeding, thereby blunting ketogenesis. Here, we...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Hepatology
Hlavní autoři: Jo, Young Suk, Ryu, Dongryeol, Maida, Adriano, Wang, Xu, Evans, Ronald M., Schoonjans, Kristina, Auwerx, Johan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618256/
https://ncbi.nlm.nih.gov/pubmed/25998209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27907
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky