Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart

BACKGROUND: The hyperpolarization-activated current, I(f), plays an important role in sinoatrial node (SAN) pacemaking. Surprisingly, the distribution of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) channels in human SAN has only been investigated at the mRNA level. Our aim was to defin...

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Pubblicato in:Circ Arrhythm Electrophysiol
Autori principali: Li, Ning, Csepe, Thomas A., Hansen, Brian J., Dobrzynski, Halina, Higgins, Robert S.D., Kilic, Ahmet, Mohler, Peter J., Janssen, Paul M.L., Rosen, Michael R., Biesiadecki, Brandon J., Fedorov, Vadim V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618238/
https://ncbi.nlm.nih.gov/pubmed/26304511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.115.003070
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