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Myeloid dysregulation in a human induced pluripotent stem cell model of PTPN11-associated juvenile myelomonocytic leukemia
Somatic PTPN11 mutations cause juvenile myelomonocytic leukemia (JMML). Germ-line PTPN11 defects cause Noonan syndrome (NS), and specific inherited mutations cause NS/JMML. Here, we report that hematopoietic cells differentiated from human induced pluripotent stem cells (hiPSCs) harboring NS/JMML-ca...
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Publicado no: | Cell Rep |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4618050/ https://ncbi.nlm.nih.gov/pubmed/26456833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.019 |
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