PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8(+) T Cell Killing

Cytotoxic CD8+ T Lymphocytes (CTL) efficiently control acute virus infections but can become exhausted when a chronic infection develops. Signaling of the inhibitory receptor PD-1 is an important mechanism for the development of virus-specific CD8+ T cell dysfunction. However, it has recently been s...

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Dettagli Bibliografici
Pubblicato in:PLoS Pathog
Autori principali: Akhmetzyanova, Ilseyar, Drabczyk, Malgorzata, Neff, C. Preston, Gibbert, Kathrin, Dietze, Kirsten K., Werner, Tanja, Liu, Jia, Chen, Lieping, Lang, Karl S., Palmer, Brent E., Dittmer, Ulf, Zelinskyy, Gennadiy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617866/
https://ncbi.nlm.nih.gov/pubmed/26484769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005224
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