Human in vitro induced T regulatory cells and memory T cells share common demethylation of specific FOXP3 promoter region

BACKGROUND: The FOXP3 gene is the master regulator for T regulatory cells and is under tight DNA methylation control at the Treg specific demethylated region (TSDR) in its first intron. This said, methylation of its promoter region, the significance of which is unknown, has also been associated with...

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Detalhes bibliográficos
Publicado no:Clin Transl Allergy
Main Authors: Bégin, Philippe, Schulze, Janika, Baron, Udo, Olek, Sven, Bauer, Rebecca N., Passerini, Laura, Baccheta, Rosa, Nadeau, Kari C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617722/
https://ncbi.nlm.nih.gov/pubmed/26500760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13601-015-0079-2
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