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Functional β-cells maturation is marked by an increase in the glucose threshold for insulin secretion and by expression of urocortin3

Insulin expressing cells that have been differentiated from human pluripotent stem cells in vitro lack the glucose responsiveness characteristic of mature β-cells. β-cell maturation in mice was studied to find genetic markers that enable screens for factors that induce bona fide β-cells in vitro. We...

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Bibliografiska uppgifter
I publikationen:Nat Biotechnol
Huvudupphovsmän: Blum, Barak, Hrvatin, Siniša, Schutz, Christian, Bonal, Claire, Rezaniaand, Alireza, Melton, Douglas A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617627/
https://ncbi.nlm.nih.gov/pubmed/22371083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2141
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