Global genetic analysis in mice unveils central role for cilia in congenital heart disease

Congenital heart disease (CHD) is the most prevalent birth defect, affecting nearly 1% of live births(1), but the incidence of CHD is up to ten fold higher in human fetuses(2,3). A genetic contribution is strongly suggested by the association of CHD with chromosome abnormalities and high recurrence...

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Publicado en:Nature
Autores principales: Li, You, Klena, Nikolai T., Gabriel, George C, Liu, Xiaoqin, Kim, Andrew J., Lemke, Kristi, Chen, Yu, Chatterjee, Bishwanath, Devine, William, Damerla, Rama Rao, Chang, Chien-fu, Yagi, Hisato, San Agustin, Jovenal T., Thahir, Mohamed, Anderton, Shane, Lawhead, Caroline, Vescovi, Anita, Pratt, Herbert, Morgan, Judy, Haynes, Leslie, Smith, Cynthia L., Eppig, Janan T., Reinholdt, Laura, Francis, Richard, Leatherbury, Linda, Ganapathiraju, Madhavi K., Tobita, Kimimasa, Pazour, Gregory J., Lo, Cecilia W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617540/
https://ncbi.nlm.nih.gov/pubmed/25807483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14269
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