Global genetic analysis in mice unveils central role for cilia in congenital heart disease

Congenital heart disease (CHD) is the most prevalent birth defect, affecting nearly 1% of live births(1), but the incidence of CHD is up to ten fold higher in human fetuses(2,3). A genetic contribution is strongly suggested by the association of CHD with chromosome abnormalities and high recurrence...

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Publicado no:Nature
Main Authors: Li, You, Klena, Nikolai T., Gabriel, George C, Liu, Xiaoqin, Kim, Andrew J., Lemke, Kristi, Chen, Yu, Chatterjee, Bishwanath, Devine, William, Damerla, Rama Rao, Chang, Chien-fu, Yagi, Hisato, San Agustin, Jovenal T., Thahir, Mohamed, Anderton, Shane, Lawhead, Caroline, Vescovi, Anita, Pratt, Herbert, Morgan, Judy, Haynes, Leslie, Smith, Cynthia L., Eppig, Janan T., Reinholdt, Laura, Francis, Richard, Leatherbury, Linda, Ganapathiraju, Madhavi K., Tobita, Kimimasa, Pazour, Gregory J., Lo, Cecilia W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617540/
https://ncbi.nlm.nih.gov/pubmed/25807483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14269
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