Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties

Cytotoxic bile acids, such as deoxycholic acid (DCA), are responsible for hepatocyte cell death during intrahepatic cholestasis. The mechanisms responsible for this effect are unclear, and recent studies conflict, pointing to either a modulation of plasma membrane structure or mitochondrial-mediated...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Sousa, Tânia, Castro, Rui E., Pinto, Sandra N., Coutinho, Ana, Lucas, Susana D., Moreira, Rui, Rodrigues, Cecília M. P., Prieto, Manuel, Fernandes, Fábio
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617403/
https://ncbi.nlm.nih.gov/pubmed/26351365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M062653
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