Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice

Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling. LPP1 expression is low in many cancer cells and tumors compared with normal tissues. It was hypothesized from studies with cultured cells that increasing LPP1 activity would decrease tum...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Tang, Xiaoyun, Benesch, Matthew G. K., Dewald, Jay, Zhao, Yuan Y., Patwardhan, Neeraj, Santos, Webster L., Curtis, Jonathan M., McMullen, Todd P. W., Brindley, David N.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617140/
https://ncbi.nlm.nih.gov/pubmed/25210149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M053462
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