Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice

Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling. LPP1 expression is low in many cancer cells and tumors compared with normal tissues. It was hypothesized from studies with cultured cells that increasing LPP1 activity would decrease tum...

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Publicat a:J Lipid Res
Autors principals: Tang, Xiaoyun, Benesch, Matthew G. K., Dewald, Jay, Zhao, Yuan Y., Patwardhan, Neeraj, Santos, Webster L., Curtis, Jonathan M., McMullen, Todd P. W., Brindley, David N.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2014
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617140/
https://ncbi.nlm.nih.gov/pubmed/25210149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M053462
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