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A Pan-Cancer Catalogue of Cancer Driver Protein Interaction Interfaces

Despite their importance in maintaining the integrity of all cellular pathways, the role of mutations on protein-protein interaction (PPI) interfaces as cancer drivers has not been systematically studied. Here we analyzed the mutation patterns of the PPI interfaces from 10,028 proteins in a pan-canc...

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Foilsithe in:PLoS Comput Biol
Main Authors: Porta-Pardo, Eduard, Garcia-Alonso, Luz, Hrabe, Thomas, Dopazo, Joaquin, Godzik, Adam
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4616621/
https://ncbi.nlm.nih.gov/pubmed/26485003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004518
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