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Overshoot during phenotypic switching of cancer cell populations

The dynamics of tumor cell populations is hotly debated: do populations derive hierarchically from a subpopulation of cancer stem cells (CSCs), or are stochastic transitions that mutate differentiated cancer cells to CSCs important? Here we argue that regulation must also be important. We sort human...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sellerio, Alessandro L., Ciusani, Emilio, Ben-Moshe, Noa Bossel, Coco, Stefania, Piccinini, Andrea, Myers, Christopher R., Sethna, James P., Giampietro, Costanza, Zapperi, Stefano, La Porta, Caterina A. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4616026/
https://ncbi.nlm.nih.gov/pubmed/26494317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15464
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