TRNA mutations that affect decoding fidelity deregulate development and the proteostasis network in zebrafish

Mutations in genes that encode tRNAs, aminoacyl-tRNA syntheases, tRNA modifying enzymes and other tRNA interacting partners are associated with neuropathies, cancer, type-II diabetes and hearing loss, but how these mutations cause disease is unclear. We have hypothesized that levels of tRNA decoding...

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Detalhes bibliográficos
Publicado no:RNA Biol
Main Authors: Reverendo, Marisa, Soares, Ana R, Pereira, Patrícia M, Carreto, Laura, Ferreira, Violeta, Gatti, Evelina, Pierre, Philippe, Moura, Gabriela R, Santos, Manuel A
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615818/
https://ncbi.nlm.nih.gov/pubmed/25483040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.32199
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