Systems analysis of genetic variation in MPTP neurotoxicity in mice

We analyzed genetic variation in severity of neuronal damage using the known dopaminergic neurotoxicant, MPTP, as a prototypical chemical denervation agent. Male mice from ten members of the BXD family of recombinant inbred strains received 12.5 mg/kg MPTP s.c. (vs. saline) and 48 h later brains wer...

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Publicat a:Neurotoxicology
Autors principals: Jones, Byron C., Miller, Diane B., O’Callaghan, James P., Lu, Lu, Unger, Erica L., Alam, Gelareh, Williams, Robert W.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615717/
https://ncbi.nlm.nih.gov/pubmed/23558233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2013.03.010
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