Genetic correlational analysis reveals no association between MPP(+) and the severity of striatal dopaminergic damage following MPTP treatment in BXD mouse strains

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a pro-neurotoxicant that must be metabolized to 1-methyl-4-phenylpyridinium (MPP(+)) and taken up into striatal dopaminergic neurons to produce neurodegeneration. Recently, we showed wide genetic variability in MPTP-associated neuronal damage in...

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Foilsithe in:Neurotoxicol Teratol
Main Authors: Jones, Byron C., O’Callaghan, James P., Lu, Lu, Williams, Robert W., Alam, Gelareh, Miller, Diane B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7401901/
https://ncbi.nlm.nih.gov/pubmed/25192776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ntt.2014.08.005
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