Local RNA flexibility perturbation of the IRES element induced by a novel ligand inhibits viral RNA translation

The internal ribosome entry site (IRES) element located at the 5´untranslated genomic region of various RNA viruses mediates cap-independent initiation of translation. Picornavirus IRES activity is highly dependent on both its structural organization and its interaction with host factors. Small mole...

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Dettagli Bibliografici
Pubblicato in:RNA Biol
Autori principali: Lozano, Gloria, Trapote, Alejandro, Ramajo, Jorge, Elduque, Xavier, Grandas, Anna, Robles, Jordi, Pedroso, Enrique, Martínez-Salas, Encarnación
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2015
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615676/
https://ncbi.nlm.nih.gov/pubmed/25775053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2015.1025190
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