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Regulation of MMP-1 expression in response to hypoxia is dependent on the intracellular redox status of metastatic bladder cancer cells.

High steady-state reactive oxygen species (ROS) production has been implicated with metastatic disease progression. We provide new evidence that this increased intracellular ROS milieu uniquely predisposes metastatic tumor cells to hypoxia-mediated regulation of the matrix metalloproteinase MMP-1. U...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochim Biophys Acta
Prif Awduron: Shin, Dong Hui, Dier, Usawadee, Melendez, Juan Andres, Hempel, Nadine
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615546/
https://ncbi.nlm.nih.gov/pubmed/26343184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2015.09.001
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