The Aplidin analogs PM01215 and PM02781 inhibit angiogenesis in vitro and in vivo

BACKGROUND: Novel synthesized analogs of Aplidin, PM01215 and PM02781, were tested for antiangiogenic effects on primary human endothelial cells in vitro and for inhibition of angiogenesis and tumor growth in vivo. METHODS: Antiangiogenic activity of both derivatives was evaluated by real-time cell...

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Pubblicato in:BMC Cancer
Autori principali: Borjan, Bojana, Steiner, Normann, Karbon, Silvia, Kern, Johann, Francesch, Andrés, Hermann, Martin, Willenbacher, Wolfgang, Gunsilius, Eberhard, Untergasser, Gerold
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615365/
https://ncbi.nlm.nih.gov/pubmed/26483043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1729-4
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