Oxidized ATM promotes abnormal proliferation of breast CAFs through maintaining intracellular redox homeostasis and activating the PI3K-AKT, MEK-ERK, and Wnt-β-catenin signaling pathways

Abnormal proliferation is one characteristic of cancer-associated fibroblasts (CAFs), which play a key role in tumorigenesis and tumor progression. Oxidative stress (OS) is the root cause of CAFs abnormal proliferation. ATM (ataxia-telangiectasia mutated protein kinase), an important redox sensor, i...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Tang, Shifu, Hou, Yixuan, Zhang, Hailong, Tu, Gang, Yang, Li, Sun, Yifan, Lang, Lei, Tang, Xi, Du, Yan-e, Zhou, Mingli, Yu, Tenghua, Xu, Liyun, Wen, Siyang, Liu, Chunming, Liu, Manran
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615140/
https://ncbi.nlm.nih.gov/pubmed/25970706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1041685
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker