Oxidized ATM promotes abnormal proliferation of breast CAFs through maintaining intracellular redox homeostasis and activating the PI3K-AKT, MEK-ERK, and Wnt-β-catenin signaling pathways

Abnormal proliferation is one characteristic of cancer-associated fibroblasts (CAFs), which play a key role in tumorigenesis and tumor progression. Oxidative stress (OS) is the root cause of CAFs abnormal proliferation. ATM (ataxia-telangiectasia mutated protein kinase), an important redox sensor, i...

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Publicado en:Cell Cycle
Autores principales: Tang, Shifu, Hou, Yixuan, Zhang, Hailong, Tu, Gang, Yang, Li, Sun, Yifan, Lang, Lei, Tang, Xi, Du, Yan-e, Zhou, Mingli, Yu, Tenghua, Xu, Liyun, Wen, Siyang, Liu, Chunming, Liu, Manran
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615140/
https://ncbi.nlm.nih.gov/pubmed/25970706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1041685
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