Spy1 induces de-ubiquitinating of RIP1 arrest and confers glioblastoma's resistance to tumor necrosis factor (TNF-α)-induced apoptosis through suppressing the association of CLIPR-59 and CYLD

Glioblastoma multiforme (GBM), a grade-IV glioma, is resistant to TNF-α induced apoptosis. CLIPR-59 modulates ubiquitination of RIP1, thus promoting Caspase-8 activation to induce apoptosis by TNF-α. Here we reported that CLIPR-59 was down-regulated in GBM cells and high-grade glioma tumor samples,...

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Библиографические подробности
Опубликовано в: :Cell Cycle
Главные авторы: Ding, Zongmei, Liu, Yonghua, Yao, Li, Wang, Donglin, Zhang, Jianguo, Cui, Gang, Yang, Xiaojing, Huang, Xianting, Liu, Fang, Shen, Aiguo
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2015
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Reports
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615064/
https://ncbi.nlm.nih.gov/pubmed/26017671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1041688
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