Different fates of oocytes with DNA double-strand breaks in vitro and in vivo

In female mice, despite the presence of slight DNA double-strand breaks (DSBs), fully grown oocytes are able to undergo meiosis resumption as indicated by germinal vesicle breakdown (GVBD); however, severe DNA DSBs do reduce and delay entry into M phase through activation of the DNA damage checkpoin...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Lin, Fei, Ma, Xue-Shan, Wang, Zhen-Bo, Wang, Zhong-Wei, Luo, Yi-Bo, Huang, Lin, Jiang, Zong-Zhe, Hu, Meng-Wen, Schatten, Heide, Sun, Qing-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614914/
https://ncbi.nlm.nih.gov/pubmed/25486355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2015.945375
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