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Inhibition of peroxisome fission, but not mitochondrial fission, increases yeast chronological lifespan

Mitochondria are key players in aging and cell death. It has been suggested that mitochondrial fragmentation, mediated by the Dnm1/Fis1 organelle fission machinery, stimulates aging and cell death. This was based on the observation that Saccharomyces cerevisiae Δdnm1 and Δfis1 mutants show an enhanc...

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Pubblicato in:Cell Cycle
Autori principali: Lefevre, Sophie D, Kumar, Sanjeev, van der Klei, Ida J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614869/
https://ncbi.nlm.nih.gov/pubmed/25840089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1029685
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