Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction

There is a connection between nutrient inputs, energy-sensing pathways, lifespan variation and aging. Despite the role of metabolic enzymes in energy homeostasis and their metabolites as nutrient signals, little is known about how their gene expression impacts lifespan. In this report, we use P-elem...

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Detalles Bibliográficos
Publicado en:Proc Biol Sci
Autores principales: Talbert, Matthew E., Barnett, Brittany, Hoff, Robert, Amella, Maria, Kuczynski, Kate, Lavington, Erik, Koury, Spencer, Brud, Evgeny, Eanes, Walter F.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Royal Society 2015
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614758/
https://ncbi.nlm.nih.gov/pubmed/26378219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rspb.2015.1646
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