Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction

There is a connection between nutrient inputs, energy-sensing pathways, lifespan variation and aging. Despite the role of metabolic enzymes in energy homeostasis and their metabolites as nutrient signals, little is known about how their gene expression impacts lifespan. In this report, we use P-elem...

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Vydáno v:Proc Biol Sci
Hlavní autoři: Talbert, Matthew E., Barnett, Brittany, Hoff, Robert, Amella, Maria, Kuczynski, Kate, Lavington, Erik, Koury, Spencer, Brud, Evgeny, Eanes, Walter F.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society 2015
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614758/
https://ncbi.nlm.nih.gov/pubmed/26378219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rspb.2015.1646
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