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High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism
Dietary folate is a major source of methyl groups required for DNA methylation, an epigenetic modification that is actively maintained and remodeled during spermatogenesis. While high-dose folic acid supplementation (up to 10 times the daily recommended dose) has been shown to improve sperm paramete...
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| Udgivet i: | Hum Mol Genet |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4614702/ https://ncbi.nlm.nih.gov/pubmed/26307085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv338 |
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