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Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome

We have previously revealed that exogenously added lithocholic bile acid (LCA) extends the chronological lifespan of the yeast Saccharomyces cerevisiae, accumulates in mitochondria and alters mitochondrial membrane lipidome. Here, we use quantitative mass spectrometry to show that LCA alters the age...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Beach, Adam, Richard, Vincent R, Bourque, Simon, Boukh-Viner, Tatiana, Kyryakov, Pavlo, Gomez-Perez, Alejandra, Arlia-Ciommo, Anthony, Feldman, Rachel, Leonov, Anna, Piano, Amanda, Svistkova, Veronika, Titorenko, Vladimir I
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614269/
https://ncbi.nlm.nih.gov/pubmed/25839782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1026493
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