Ablation of CD8α(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice

Clinical complications of atherosclerosis are almost exclusively linked to destabilization of the atherosclerotic plaque. Batf3-dependent dendritic cells specialize in cross-presentation of necrotic tissue-derived epitopes to directly activate cytolytic CD8 Tcells. The mature plaque (necrotic, conta...

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Pubblicato in:Sci Rep
Autori principali: Legein, Bart, Janssen, Edith M., Theelen, Thomas L., Gijbels, Marion J., Walraven, Joep, Klarquist, Jared S., Hennies, Cassandra M., Wouters, Kristiaan, Seijkens, Tom T.P., Wijnands, Erwin, Sluimer, Judith C., Lutgens, Esther, Zenke, Martin, Hildner, Kai, Biessen, Erik A.L., Temmerman, Lieve
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614009/
https://ncbi.nlm.nih.gov/pubmed/26486587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15414
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