Nuclear localized Akt enhances breast cancer stem-like cells through counter-regulation of p21(Waf1/Cip1) and p27(kip1)

Cancer stem-like cells (CSCs) are a rare subpopulation of cancer cells capable of propagating the disease and causing cancer recurrence. In this study, we found that the cellular localization of PKB/Akt kinase affects the maintenance of CSCs. When Akt tagged with nuclear localization signal (Akt-NLS...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Jain, Mayur Vilas, Jangamreddy, Jaganmohan R, Grabarek, Jerzy, Schweizer, Frank, Klonisch, Thomas, Cieślar-Pobuda, Artur, Łos, Marek J
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613986/
https://ncbi.nlm.nih.gov/pubmed/26030190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1041692
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