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Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as ‘well expressed’, ‘poorly expressed’ or ‘salvageable’

Multiple mis-sense variants of TRPA1 (transient receptor potential A1) and TRPM8 (transient receptor potential M8) are recorded in the human genome single nt polymorphism (SNP) database, but their potential impact on channel signalling in patho-physiology is not fully explored. Variants, mostly quit...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Morgan, Kevin, Sadofsky, Laura Rachel, Morice, Alyn Hugh
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613725/
https://ncbi.nlm.nih.gov/pubmed/26330615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20150108
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