The class II transactivator (CIITA) is regulated by post-translational modification cross-talk between ERK1/2 phosphorylation, mono-ubiquitination and Lys(63) ubiquitination

The class II transactivator (CIITA) is known as the master regulator for the major histocompatibility class II (MHC II) molecules. CIITA is dynamically regulated through a series of intricate post-translational modifications (PTMs). CIITA's role is to initiate transcription of MHC II genes, whi...

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Detalles Bibliográficos
Publicado en:Biosci Rep
Main Authors: Morgan, Julie E., Shanderson, Ronald L., Boyd, Nathaniel H., Cacan, Ercan, Greer, Susanna F.
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2015
Assuntos:
Original Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613680/
https://ncbi.nlm.nih.gov/pubmed/26181363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20150091
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