Targeted deletion of the ara operon of Salmonella typhimurium enhances L-arabinose accumulation and drives P(BAD)-promoted expression of anti-cancer toxins and imaging agents

Tumor-specific expression of antitumor drugs can be achieved using attenuated Salmonella typhimurium harboring the P(BAD) promoter, which is induced by L-arabinose. However, L-arabinose does not accumulate because it is metabolized to D-xylulose-5-P by enzymes encoded by the ara operon in Salmonella...

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Publicat a:Cell Cycle
Autors principals: Hong, Hyun, Lim, Daejin, Kim, Geun-Joong, Park, Seung-Hwan, Sik Kim, Hyeon, Hong, Yeongjin, Choy, Hyon E, Min, Jung-Joon
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2014
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Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613543/
https://ncbi.nlm.nih.gov/pubmed/25486570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.949527
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