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Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members
PLK (Polo-like kinase) inhibitors, such as BI-2536, have been reported to suppress IFNB (encoding IFNβ, interferon β) gene transcription induced by ligands that activate TLR3 (Toll-like receptor 3) and TLR4. In the present study, we found that BI-2536 is likely to exert this effect by preventing the...
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| Foilsithe in: | Biochem J |
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| Main Authors: | , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Portland Press Ltd.
2015
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4613535/ https://ncbi.nlm.nih.gov/pubmed/25891802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20141523 |
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