Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention

Nrf2 (nuclear factor erytheroid-derived-2-like 2) transcriptional programmes are activated by a variety of cellular stress conditions to maintain cellular homoeostasis. Under non-stress conditions, Nrf2 is under tight regulation by the ubiquitin proteasome system (UPS). Detailed mechanistic investig...

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Bibliographische Detailangaben
Veröffentlicht in:Biochem Soc Trans
Hauptverfasser: Harder, Bryan, Jiang, Tao, Wu, Tongde, Tao, Shasha, de la Vega, Montserrat Rojo, Tian, Wang, Chapman, Eli, Zhang, Donna D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2015
Schlagworte:
Biochemical Society Focused Meetings
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613518/
https://ncbi.nlm.nih.gov/pubmed/26551712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20150020
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