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High variability of genomic instability and gene expression profiling in different HeLa clones

The HeLa cell line is one of the most popular cell lines in biomedical research, despite its well-known chromosomal instability. We compared the genomic and transcriptomic profiles of 4 different HeLa batches and showed that the gain and loss of genomic material varies widely between batches, drasti...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Frattini, Annalisa, Fabbri, Marco, Valli, Roberto, De Paoli, Elena, Montalbano, Giuseppe, Gribaldo, Laura, Pasquali, Francesco, Maserati, Emanuela
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613361/
https://ncbi.nlm.nih.gov/pubmed/26483214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15377
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