A Novel Ligustrazine Derivative T-VA Prevents Neurotoxicity in Differentiated PC12 Cells and Protects the Brain against Ischemia Injury in MCAO Rats

Broad-spectrum drugs appear to be more promising for the treatment of acute ischemic stroke. In our previous work, a new ligustrazine derivative (3,5,6-trimethylpyrazin-2-yl) methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate (T-VA) showed neuroprotective effect on injured PC12 cells...

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Détails bibliographiques
Publié dans:Int J Mol Sci
Auteurs principaux: Li, Guoling, Tian, Yufei, Zhang, Yuzhong, Hong, Ying, Hao, Yingzhi, Chen, Chunxiao, Wang, Penglong, Lei, Haimin
Format: Artigo
Langue:Inglês
Publié: MDPI 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613278/
https://ncbi.nlm.nih.gov/pubmed/26370988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms160921759
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