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HMGB1 Contributes to the Expression of P-Glycoprotein in Mouse Epileptic Brain through Toll-Like Receptor 4 and Receptor for Advanced Glycation End Products

The objective of the present study was to investigate the role of high-mobility group box-1 (HMGB1) in the seizure-induced P-glycoprotein (P-gp) overexpression and the underlying mechanism. Kainic acid (KA)-induced mouse seizure model was used for in vivo experiments. Male C57BL/6 mice were divided...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:PLoS One
Main Authors: Chen, Yan, Huang, Xian-Jing, Yu, Nian, Xie, Yuan, Zhang, Kang, Wen, Fang, Liu, Hao, Di, Qing
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613137/
https://ncbi.nlm.nih.gov/pubmed/26485677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140918
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