Allopregnanolone attenuates Aβ(25-35)-induced neurotoxicity in PC12 cells by reducing oxidative stress

Massive accumulation of amyloid beta (Aβ) has been implicated as a pivotal event in the pathogenesis of Alzheimer’s disease. The underlying mechanisms of Aβ-induced neurotoxicity include generation of reactive oxidative species (ROS), inflammation, and neurons loss. Allopregnano-lone (APα), a neuros...

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Vydáno v:Int J Clin Exp Med
Hlavní autoři: Qian, Xiaowei, Cao, Hong, Ma, Qian, Wang, Qinsai, He, Wei, Qin, Peishun, Ji, Bin, Yuan, Kaiming, Yang, Fanghua, Liu, Xuhua, Lian, Qingquan, Li, Jun
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2015
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612987/
https://ncbi.nlm.nih.gov/pubmed/26550302
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