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Allosteric interactions between receptor site 3 and 4 of voltage-gated sodium channels: a novel perspective for the underlying mechanism of scorpion sting-induced pain
BACKGROUND: BmK I, a site-3-specific modulator of voltage-gated sodium channels (VGSCs), causes pain and hyperalgesia in rats, while BmK IT2, a site-4-specific modulator of VGSCs, suppresses pain-related responses. A stronger pain-related effect has been previously attributed to Buthus martensi Kars...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Venom Anim Toxins Incl Trop Dis |
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| Κύριοι συγγραφείς: | , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
BioMed Central
2015
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4612427/ https://ncbi.nlm.nih.gov/pubmed/26491429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40409-015-0043-6 |
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