Inconclusive flow cytometric surface light chain results; can cytoplasmic light chains, Bcl-2 expression and PCR clonality analysis improve accuracy of cytological diagnoses in B-cell lymphomas?

BACKGROUND: Flow cytometric immunophenotyping (FCI), is widely used in cytology for distinguishing between B-cell lymphoma (BCL) and reactive lymphocytic proliferations (RLP), mainly by identifying monotypic B-cell populations. Since this cannot always be determined by ratios of surface immunoglobul...

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Udgivet i:Diagn Pathol
Main Authors: Brozic, Andreja, Pohar Marinsek, Ziva, Novakovic, Srdjan, Kloboves Prevodnik, Veronika
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612408/
https://ncbi.nlm.nih.gov/pubmed/26482649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13000-015-0427-5
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