A phase 1 study evaluating the pharmacokinetics and preliminary efficacy of veliparib (ABT-888) in combination with carboplatin/paclitaxel in Japanese subjects with non-small cell lung cancer (NSCLC)

INTRODUCTION: Veliparib is a potent, orally bioavailable PARP inhibitor that enhances efficacy of DNA-damaging chemotherapeutic agents. The study objectives were to determine the recommended phase 2 dose (RPTD) of veliparib plus carboplatin and paclitaxel, and assess pharmacokinetics (PK), tolerabil...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Mizugaki, Hidenori, Yamamoto, Noboru, Nokihara, Hiroshi, Fujiwara, Yutaka, Horinouchi, Hidehito, Kanda, Shintaro, Kitazono, Satoru, Yagishita, Shigehiro, Xiong, Hao, Qian, Jane, Hashiba, Hideyuki, Shepherd, Stacie P., Giranda, Vincent, Tamura, Tomohide
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612330/
https://ncbi.nlm.nih.gov/pubmed/26433581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2876-7
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