p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency

Histone Nuclear Factor P (HINFP) is essential for expression of histone H4 genes. Ablation of Hinfp and consequential depletion of histones alter nucleosome spacing and cause stalled replication and DNA damage that ultimately result in genomic instability. Faithful replication and packaging of newly...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Ghule, Prachi N, Xie, Rong-Lin, Colby, Jennifer L, Jones, Stephen N, Lian, Jane B, van Wijnen, Andre J, Stein, Janet L, Stein, Gary S
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612103/
https://ncbi.nlm.nih.gov/pubmed/26030398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1049783
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