p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency

Histone Nuclear Factor P (HINFP) is essential for expression of histone H4 genes. Ablation of Hinfp and consequential depletion of histones alter nucleosome spacing and cause stalled replication and DNA damage that ultimately result in genomic instability. Faithful replication and packaging of newly...

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Pubblicato in:Cell Cycle
Autori principali: Ghule, Prachi N, Xie, Rong-Lin, Colby, Jennifer L, Jones, Stephen N, Lian, Jane B, van Wijnen, Andre J, Stein, Janet L, Stein, Gary S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612103/
https://ncbi.nlm.nih.gov/pubmed/26030398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1049783
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