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p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency
Histone Nuclear Factor P (HINFP) is essential for expression of histone H4 genes. Ablation of Hinfp and consequential depletion of histones alter nucleosome spacing and cause stalled replication and DNA damage that ultimately result in genomic instability. Faithful replication and packaging of newly...
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| Опубликовано в: : | Cell Cycle |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Taylor & Francis
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4612103/ https://ncbi.nlm.nih.gov/pubmed/26030398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1049783 |
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