Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms

The cohesin complex (consisting of Rad21, Smc1a, Smc3, and Stag2 proteins) is critically important for proper sister chromatid separation during mitosis. Mutations in the cohesin complex were recently identified in a variety of human malignancies including acute myeloid leukemia (AML). To address th...

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Gepubliceerd in:J Exp Med
Hoofdauteurs: Mullenders, Jasper, Aranda-Orgilles, Beatriz, Lhoumaud, Priscillia, Keller, Matthew, Pae, Juhee, Wang, Kun, Kayembe, Clarisse, Rocha, Pedro P., Raviram, Ramya, Gong, Yixiao, Premsrirut, Prem K., Tsirigos, Aristotelis, Bonneau, Richard, Skok, Jane A., Cimmino, Luisa, Hoehn, Daniela, Aifantis, Iannis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612095/
https://ncbi.nlm.nih.gov/pubmed/26438359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151323
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