Augmentation of NAD(+) by NQO1 attenuates cisplatin-mediated hearing impairment

Cisplatin (cis-diaminedichloroplatinum-II) is an extensively used chemotherapeutic agent, and one of its most adverse effects is ototoxicity. A number of studies have demonstrated that these effects are related to oxidative stress and DNA damage. However, the precise mechanism underlying cisplatin-a...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Kim, H-J, Oh, G-S, Shen, A, Lee, S-B, Choe, S-K, Kwon, K-B, Lee, S, Seo, K-S, Kwak, T H, Park, R, So, H-S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611728/
https://ncbi.nlm.nih.gov/pubmed/24922076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.255
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